RESUMO
En un estudio multicéntrico se determinó la concentración de serotonina plaqueraria en 47 pacientes depresivos hallándose que un 40.4 por cento de los mismos presenta valores inferiores al rango normal. Los valores obtenidos son comparables a los de un estudio preliminar. En 19 casos se determinó asimismo la concentración de serotonina extracelular en plasma. Los pacientes con cifras normales de serotonina plaquetaria arrojaron un valor de serotonina plasmática de 4.6ñ2.1 ng/ml mientras que los pacientes con cifras bajas dieron un valor de 2.2ñ1.3 ng/ml, una disminuicción estadísticamente significativa que indicaría una falla en los mecanismos de formación de este neurotransmisor. Finalmente se determinó la serotonina plaquetaria en 41 pacientes tratados con inhibidores de recaptación de la serotonina. Alrededor del 60 por cento de ellos presenta cifras notablemente inferiores a las normales. De todos modos, la presencia de pacientes con cifras normales o cercanas a las mismas indica la necesidad de evaluar las respuestas terapéuticas individuales frente a los distintos valores obtenidos
Assuntos
DepressãoRESUMO
Se pasa una revista general a valores de fenetilamina(FEA) en ratas y sus cambios luego de la administración de diferentes drogas. Se presentam valores de FEA urinaria en 4710 pacientes psiquiátricos con sintomatología depresiva. Se comparam valores de FEA en orina de 24h con los de su metabolito, el ácido fenilacético total (AFAT) en orina de 24h. Se hace un estudio comparativo de valores urinarios y plasmáticos de AFAT concluyéndose que en pacientes depresivos se encuentra una disminuición de AFAT en urina y que la determinación de AFAT en plasma bien puede usarse como marcador de enfermedades depresivas
Assuntos
Humanos , Animais , Fenetilaminas/análise , Fenetilaminas/sangue , Fenetilaminas/urina , Fenilacetatos/metabolismo , Transtorno Depressivo/sangue , Transtorno Depressivo/urinaRESUMO
We have studied the content of platelet serotonin in 31 depressive patients free of medication and in 29 controls. The depressive patients have been selected according to clinic diagnosis and to urinary phenylethylamine (PEA) and total phenylacetic acid (PAA) values, because low levels of these two substances are for us almost a constant in endogenous depressive patients. For the control group we selected 23 out of 29 cases studied, which had all urinary PEA and PAA values within the normal range published by us previously. In this group platelet serotonin content was of 527-900 ng/10 9 platelets with a mean of 698 +/- 125 ng/10 9 platelets. In the depressive group, taking account of platelets serotonin content we could differentiate two subgroups. In a group of 19 patients we found lower values, 157-513 ng/10 9 platelets with a mean of 407 +/- 102 ng/10 9. In the other 13 patients group we found platelet serotonin levels similar to those of the control group, 552-780 ng 10 9 platelets with a mean of 658 +/- 93 ng/10 9 platelets. Accepting blood platelets as models for serotoninergic nerve terminals, we suppose that the response of depressive patients to serotonin reuptake blockers treatment should be different in both subgroups, which is at present matter of study in our laboratory.
Assuntos
Transtorno Depressivo/metabolismo , Serotonina/sangue , Plaquetas , Humanos , Fenetilaminas/urina , Fenilacetatos/urinaRESUMO
We have studied the content of platelet serotonin in 31 depressive patients free of medication and in 29 controls. The depressive patients have been selected according to clinic diagnosis and to urinary phenylethylamine (PEA) and total phenylacetic acid (PAA) values, because low levels of these two substances are for us almost a constant in endogenous depressive patients. For the control group we selected 23 out of 29 cases studied, which had all urinary PEA and PAA values within the normal range published by us previously. In this group platelet serotonin content was of 527-900 ng/10 9 platelets with a mean of 698 +/- 125 ng/10 9 platelets. In the depressive group, taking account of platelets serotonin content we could differentiate two subgroups. In a group of 19 patients we found lower values, 157-513 ng/10 9 platelets with a mean of 407 +/- 102 ng/10 9. In the other 13 patients group we found platelet serotonin levels similar to those of the control group, 552-780 ng 10 9 platelets with a mean of 658 +/- 93 ng/10 9 platelets. Accepting blood platelets as models for serotoninergic nerve terminals, we suppose that the response of depressive patients to serotonin reuptake blockers treatment should be different in both subgroups, which is at present matter of study in our laboratory.
RESUMO
N,N-dimethiltryptamine (DMT) in urine has been quantified on an 83-psychiatric patient sample. Sample covered patients who had sometimes been administered neuroleptic drugs as well as patients with some particular symptomatology associated to psychotic disorders such as hallucinations, delusions, perception disorders, etc. 43.3% (36 cases) evidenced an abnormally high DMT in urine (0.9-13.5 mcg/24 h). Higher values were more frequently found in both schizophrenic patients, and non-schizophrenic patients with either hallucinations, delusions, anorexia or bulimia. Most patients with DMT normal values (< 0.5 mcg/24 h) presented either mental retardation, cerebral atrophy or dysrhythmias. A very good correlation was found between urinary DMT abnormally high values, and patients' improvement after such patients had been treated with neuroleptic drugs.
Assuntos
Transtornos Mentais/urina , N,N-Dimetiltriptamina/urina , Adolescente , Adulto , Antipsicóticos/uso terapêutico , Biomarcadores/urina , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Transtornos Mentais/tratamento farmacológico , Pessoa de Meia-IdadeRESUMO
N,N-dimethiltryptamine (DMT) in urine has been quantified on an 83-psychiatric patient sample. Sample covered patients who had sometimes been administered neuroleptic drugs as well as patients with some particular symptomatology associated to psychotic disorders such as hallucinations, delusions, perception disorders, etc. 43.3
(36 cases) evidenced an abnormally high DMT in urine (0.9-13.5 mcg/24 h). Higher values were more frequently found in both schizophrenic patients, and non-schizophrenic patients with either hallucinations, delusions, anorexia or bulimia. Most patients with DMT normal values (< 0.5 mcg/24 h) presented either mental retardation, cerebral atrophy or dysrhythmias. A very good correlation was found between urinary DMT abnormally high values, and patients improvement after such patients had been treated with neuroleptic drugs.
